Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; inner mitochondrial membrane organization; and negative regulation of release of cytochrome c from mitochondria. Located in endoplasmic reticulum membrane and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GHITM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GHITM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GHITM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:83,897,678–83,898,230 | 241.6 kb | Distal (>10kb) Multiome | 82 | |
| chr10:83,908,468–83,909,852 | 230.4 kb | Distal (>10kb) Multiome | 186 | |
| chr10:84,138,872–84,140,243 | 43 bp | At TSS Multiome | 1010 | |
| chr10:84,194,013–84,195,432 | 55.1 kb | Distal (>10kb) Multiome | 319 | |
| chr10:84,214,110–84,214,878 | 75.1 kb | Distal (>10kb) Multiome | 208 | |
| chr10:84,237,063–84,237,847 | 97.9 kb | Distal (>10kb) Multiome | 222 | |
| chr10:84,293,329–84,294,247 | 154.3 kb | Distal (>10kb) Multiome | 402 | |
| chr10:84,327,638–84,329,551 | 189.1 kb | Distal (>10kb) Multiome | 916 |
Genomic view of the GHITM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.