Enables identical protein binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GFOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GFOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GFOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:13,328,084–13,329,043 | 159.0 kb | Distal (>10kb) Multiome | 848 | |
| chr6:13,422,574–13,423,098 | 64.8 kb | Distal (>10kb) Multiome | 180 | |
| chr6:13,480,581–13,481,344 | 6.3 kb | Proximal (<10kb) | 81 | |
| chr6:13,485,963–13,488,715 | 125 bp | At TSS Multiome | 753 | |
| chr6:13,573,806–13,575,472 | 86.9 kb | Distal (>10kb) Multiome | 1136 | |
| chr6:13,614,519–13,616,157 | 127.7 kb | Distal (>10kb) Multiome | 1137 | |
| chr6:13,710,505–13,712,451 | 224.4 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the GFOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.