Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GFM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GFM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GFM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:158,570,578–158,571,791 | 73.4 kb | Distal (>10kb) Multiome | 632 | |
| chr3:158,634,616–158,635,069 | 9.5 kb | Proximal (<10kb) | 40 | |
| chr3:158,643,965–158,644,957 | 67 bp | At TSS Multiome | 928 | |
| chr3:158,671,766–158,673,071 | 28.1 kb | Distal (>10kb) Multiome | 479 | |
| chr3:158,731,475–158,733,286 | 87.8 kb | Distal (>10kb) Multiome | 470 | |
| chr3:158,801,057–158,802,803 | 157.4 kb | Distal (>10kb) Multiome | 932 | |
| chr3:158,905,172–158,906,095 | 260.9 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the GFM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.