Contributes to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 41. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GATB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:151,488,949–151,490,034 | 271.4 kb | Distal (>10kb) Multiome | 186 | |
| chr4:151,637,197–151,637,951 | 123.4 kb | Distal (>10kb) Multiome | 96 | |
| chr4:151,639,607–151,640,861 | 120.6 kb | Distal (>10kb) Multiome | 93 | |
| chr4:151,760,489–151,761,571 | 97 bp | At TSS Multiome | 777 | |
| chr4:152,004,383–152,005,466 | 244.0 kb | Distal (>10kb) Multiome | 107 | |
| chr4:152,045,407–152,046,556 | 285.0 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the GATB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.