The protein encoded by this gene contains a zinc finger at the N-terminus, and is thought to bind to a histone modification site that regulates gene expression. Mutations in this gene have been associated with autosomal recessive dilated cardiomyopathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Cluster | Dir | NES | padj | Bind | OR | padj (bind) |
|---|
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by GATAD1 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to GATAD1 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where GATAD1 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for GATAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,133,257–92,135,349 | 313.7 kb | Distal (>10kb) Multiome HiCAR | 1155 | |
| chr7:92,178,862–92,179,934 | 268.4 kb | Distal (>10kb) Multiome | 612 | |
| chr7:92,245,288–92,246,980 | 201.4 kb | Distal (>10kb) Multiome | 964 | |
| chr7:92,424,381–92,424,856 | 22.8 kb | Distal (>10kb) Multiome | 634 | |
| chr7:92,447,026–92,448,601 | 1 bp | At TSS Multiome | 973 | |
| chr7:92,483,511–92,484,016 | 36.3 kb | Distal (>10kb) Multiome | 84 | |
| chr7:92,527,585–92,529,221 | 81.1 kb | Distal (>10kb) Multiome | 921 | |
| chr7:92,589,648–92,590,940 | 142.8 kb | Distal (>10kb) Multiome | 1025 | |
| chr7:92,608,546–92,609,216 | 161.4 kb | Distal (>10kb) Multiome | 301 |
Genomic view of the GATAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.