Enables actin binding activity and microtubule binding activity. Involved in actin cytoskeleton organization and microtubule cytoskeleton organization. Located in actin cytoskeleton and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GAS2L3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAS2L3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAS2L3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:100,404,822–100,405,325 | 168.7 kb | Distal (>10kb) Multiome | 212 | |
| chr12:100,569,989–100,570,292 | 3.4 kb | Proximal (<10kb) | 4 | |
| chr12:100,573,087–100,574,669 | 57 bp | At TSS Multiome | 880 | |
| chr12:100,578,596–100,578,756 | 4.9 kb | Proximal (<10kb) | 3 | |
| chr12:100,715,591–100,717,971 | 143.5 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the GAS2L3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.