This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for GAS2L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAS2L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAS2L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,029,712–29,031,115 | 276.2 kb | Distal (>10kb) Multiome | 773 | |
| chr22:29,071,484–29,071,874 | 235.5 kb | Distal (>10kb) Multiome | 332 | |
| chr22:29,072,494–29,074,480 | 234.1 kb | Distal (>10kb) Multiome | 537 | |
| chr22:29,205,602–29,206,473 | 101.0 kb | Distal (>10kb) Multiome | 378 | |
| chr22:29,267,574–29,268,917 | 38.9 kb | Distal (>10kb) Multiome | 969 | |
| chr22:29,304,664–29,307,808 | 105 bp | At TSS Multiome | 839 | |
| chr22:29,311,043–29,311,236 | 4.0 kb | Proximal (<10kb) | 299 | |
| chr22:29,313,065–29,313,784 | 6.3 kb | Proximal (<10kb) Multiome | 274 | |
| chr22:29,315,074–29,316,064 | 8.6 kb | Proximal (<10kb) Multiome | 242 | |
| chr22:29,388,161–29,388,971 | 81.6 kb | Distal (>10kb) Multiome | 740 | |
| chr22:29,431,916–29,432,715 | 125.3 kb | Distal (>10kb) Multiome | 14 | |
| chr22:29,470,132–29,470,844 | 163.4 kb | Distal (>10kb) Multiome | 437 | |
| chr22:29,480,003–29,481,437 | 174.0 kb | Distal (>10kb) Multiome | 384 | |
| chr22:29,553,345–29,553,988 | 246.7 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,580,084–29,581,520 | 274.1 kb | Distal (>10kb) Multiome | 856 | |
| chr22:29,603,006–29,604,162 | 296.5 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the GAS2L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.