Transcription factors with Perturb-seq knockdown data for GARS1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GARS1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GARS1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:30,472,499–30,473,444 | 121.8 kb | Distal (>10kb) Multiome | 123 | |
| chr7:30,478,426–30,479,128 | 116.1 kb | Distal (>10kb) Multiome | 756 | |
| chr7:30,504,202–30,505,455 | 89.8 kb | Distal (>10kb) Multiome | 824 | |
| chr7:30,544,196–30,544,698 | 50.2 kb | Distal (>10kb) Multiome | 40 | |
| chr7:30,594,119–30,595,511 | 134 bp | At TSS Multiome | 1016 | |
| chr7:30,681,420–30,682,927 | 87.8 kb | Distal (>10kb) Multiome | 319 | |
| chr7:30,699,970–30,700,584 | 105.6 kb | Distal (>10kb) Multiome | 149 | |
| chr7:30,771,029–30,771,985 | 176.7 kb | Distal (>10kb) Multiome | 536 |
Genomic view of the GARS1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.