Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GARNL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GARNL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GARNL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,027,806–127,028,318 | 197.2 kb | Distal (>10kb) Multiome | 28 | |
| chr9:127,111,996–127,112,450 | 113.0 kb | Distal (>10kb) Multiome | 160 | |
| chr9:127,122,192–127,123,298 | 102.4 kb | Distal (>10kb) Multiome | 426 | |
| chr9:127,129,382–127,130,064 | 95.6 kb | Distal (>10kb) Multiome | 117 | |
| chr9:127,199,063–127,199,676 | 25.9 kb | Distal (>10kb) Multiome | 315 | |
| chr9:127,214,497–127,214,700 | 9.9 kb | Proximal (<10kb) | 174 | |
| chr9:127,223,725–127,226,151 | 467 bp | At TSS Multiome | 713 | |
| chr9:127,244,905–127,245,629 | 20.0 kb | Distal (>10kb) Multiome | 447 | |
| chr9:127,253,417–127,253,754 | 8.1 kb | Proximal (<10kb) | 34 | |
| chr9:127,396,281–127,398,388 | 171.7 kb | Distal (>10kb) Multiome HiCAR | 843 | |
| chr9:127,423,809–127,424,734 | 199.1 kb | Distal (>10kb) Multiome | 791 | |
| chr9:127,450,607–127,452,473 | 226.2 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the GARNL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.