This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GALNT8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNT8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNT8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:4,441,229–4,442,210 | 278.6 kb | Distal (>10kb) Multiome | 241 | |
| chr12:4,538,204–4,539,165 | 181.7 kb | Distal (>10kb) Multiome | 740 | |
| chr12:4,562,041–4,562,555 | 158.2 kb | Distal (>10kb) Multiome | 486 | |
| chr12:4,604,713–4,605,166 | 115.5 kb | Distal (>10kb) Multiome | 580 | |
| chr12:4,648,527–4,649,423 | 71.4 kb | Distal (>10kb) Multiome | 645 | |
| chr12:4,720,395–4,720,946 | 331 bp | At TSS Multiome | 69 | |
| chr12:4,809,137–4,810,290 | 89.0 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr12:4,908,662–4,909,110 | 188.5 kb | Distal (>10kb) Multiome | 190 | |
| chr12:4,962,592–4,963,454 | 242.8 kb | Distal (>10kb) Multiome | 190 | |
| chr12:5,043,628–5,044,415 | 323.7 kb | Distal (>10kb) Multiome | 156 |
Genomic view of the GALNT8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.