This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GALNT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,289,760–35,290,683 | 290.9 kb | Distal (>10kb) Multiome | 970 | |
| chr18:35,343,705–35,344,835 | 236.8 kb | Distal (>10kb) Multiome | 916 | |
| chr18:35,376,423–35,377,702 | 203.9 kb | Distal (>10kb) Multiome | 673 | |
| chr18:35,488,095–35,488,748 | 92.5 kb | Distal (>10kb) Multiome | 82 | |
| chr18:35,496,979–35,498,336 | 83.3 kb | Distal (>10kb) Multiome | 1055 | |
| chr18:35,580,775–35,581,562 | 397 bp | At TSS Multiome | 563 | |
| chr18:35,581,931–35,582,297 | 815 bp | At TSS | 295 | |
| chr18:35,589,089–35,589,292 | 8.0 kb | Proximal (<10kb) | 69 | |
| chr18:35,827,502–35,828,102 | 246.6 kb | Distal (>10kb) Multiome | 227 | |
| chr18:35,849,802–35,850,882 | 269.1 kb | Distal (>10kb) Multiome | 177 | |
| chr18:35,851,060–35,852,119 | 270.4 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the GALNT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.