The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for GABBR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABBR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABBR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:98,315,414–98,316,053 | 391.8 kb | Distal (>10kb) Multiome HiCAR | 373 | |
| chr9:98,706,970–98,708,078 | 53 bp | At TSS Multiome | 352 | |
| chr9:98,708,439–98,709,531 | 1.7 kb | Proximal (<10kb) Multiome | 190 | |
| chr9:98,791,228–98,791,931 | 83.9 kb | Distal (>10kb) Multiome | 424 | |
| chr9:98,792,170–98,792,795 | 85.3 kb | Distal (>10kb) Multiome | 57 | |
| chr9:98,796,038–98,797,077 | 89.1 kb | Distal (>10kb) Multiome | 590 | |
| chr9:98,807,121–98,808,181 | 100.2 kb | Distal (>10kb) Multiome | 366 | |
| chr9:98,848,233–98,848,856 | 141.2 kb | Distal (>10kb) Multiome | 494 | |
| chr9:98,850,508–98,851,258 | 143.5 kb | Distal (>10kb) Multiome | 114 | |
| chr9:98,943,613–98,944,680 | 236.5 kb | Distal (>10kb) Multiome | 250 | |
| chr9:98,974,780–98,975,407 | 267.7 kb | Distal (>10kb) Multiome | 363 | |
| chr9:98,998,541–98,999,328 | 291.6 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the GABBR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.