Enables molecular condensate scaffold activity. Involved in positive regulation of stress granule assembly; protein homooligomerization; and stress granule assembly. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for G3BP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = G3BP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of G3BP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:75,513,821–75,515,182 | 210.0 kb | Distal (>10kb) Multiome | 933 | |
| chr4:75,573,437–75,573,948 | 150.8 kb | Distal (>10kb) Multiome | 380 | |
| chr4:75,630,110–75,631,197 | 93.8 kb | Distal (>10kb) Multiome | 498 | |
| chr4:75,672,443–75,674,197 | 51.0 kb | Distal (>10kb) Multiome | 969 | |
| chr4:75,704,833–75,705,758 | 19.0 kb | Distal (>10kb) Multiome | 191 | |
| chr4:75,723,996–75,725,607 | 112 bp | At TSS Multiome | 996 | |
| chr4:75,848,100–75,848,739 | 124.0 kb | Distal (>10kb) Multiome | 281 | |
| chr4:75,939,639–75,941,475 | 216.6 kb | Distal (>10kb) Multiome | 762 | |
| chr4:75,990,621–75,991,159 | 266.5 kb | Distal (>10kb) Multiome | 782 |
Genomic view of the G3BP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.