Enables ubiquitin-like ligase-substrate adaptor activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of ubiquitin protein ligase activity. Located in nuclear membrane and nucleoplasm. Implicated in developmental and epileptic encephalopathy 109. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FZR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,224,482–3,224,897 | 281.7 kb | Distal (>10kb) Multiome | 253 | |
| chr19:3,275,036–3,277,129 | 230.0 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,284,276–3,286,396 | 220.7 kb | Distal (>10kb) Multiome | 555 | |
| chr19:3,360,114–3,360,563 | 146.0 kb | Distal (>10kb) Multiome | 430 | |
| chr19:3,434,837–3,435,636 | 71.1 kb | Distal (>10kb) Multiome | 777 | |
| chr19:3,441,686–3,442,206 | 64.4 kb | Distal (>10kb) Multiome | 86 | |
| chr19:3,444,085–3,444,710 | 61.8 kb | Distal (>10kb) Multiome | 150 | |
| chr19:3,500,403–3,501,074 | 5.5 kb | Proximal (<10kb) Multiome | 886 | |
| chr19:3,505,575–3,507,061 | 202 bp | At TSS Multiome | 838 | |
| chr19:3,507,612–3,508,152 | 1.3 kb | Proximal (<10kb) | 266 | |
| chr19:3,557,019–3,558,238 | 51.4 kb | Distal (>10kb) Multiome | 811 | |
| chr19:3,572,147–3,574,664 | 66.4 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,576,363–3,578,543 | 72.0 kb | Distal (>10kb) Multiome | 346 | |
| chr19:3,606,342–3,607,177 | 100.5 kb | Distal (>10kb) Multiome | 377 | |
| chr19:3,626,518–3,627,304 | 120.7 kb | Distal (>10kb) Multiome | 833 | |
| chr19:3,699,968–3,700,899 | 194.2 kb | Distal (>10kb) Multiome | 489 | |
| chr19:3,721,462–3,721,997 | 215.3 kb | Distal (>10kb) Multiome | 760 | |
| chr19:3,722,652–3,723,093 | 216.7 kb | Distal (>10kb) Multiome | 106 | |
| chr19:3,761,103–3,762,150 | 255.3 kb | Distal (>10kb) Multiome | 839 | |
| chr19:3,762,300–3,763,344 | 256.6 kb | Distal (>10kb) Multiome | 817 | |
| chr19:3,786,012–3,786,456 | 279.9 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the FZR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.