This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for FZD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:28,318,563–28,319,487 | 175.2 kb | Distal (>10kb) Multiome | 205 | |
| chr8:28,384,745–28,386,965 | 107.8 kb | Distal (>10kb) Multiome | 674 | |
| chr8:28,401,081–28,402,986 | 92.1 kb | Distal (>10kb) Multiome | 941 | |
| chr8:28,411,636–28,412,462 | 82.2 kb | Distal (>10kb) Multiome | 805 | |
| chr8:28,429,151–28,429,912 | 64.7 kb | Distal (>10kb) Multiome | 77 | |
| chr8:28,490,087–28,490,872 | 3.8 kb | Proximal (<10kb) Multiome | 535 | |
| chr8:28,493,649–28,495,132 | at TSS | At TSS Multiome | 656 | |
| chr8:28,622,031–28,623,620 | 128.4 kb | Distal (>10kb) Multiome | 828 | |
| chr8:28,700,738–28,702,456 | 207.3 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the FZD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.