This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for FZD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,307,755–44,309,164 | 249.0 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 242.2 kb | Distal (>10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 241.0 kb | Distal (>10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 232.6 kb | Distal (>10kb) Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 230.5 kb | Distal (>10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 212.3 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 202.8 kb | Distal (>10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 193.6 kb | Distal (>10kb) Multiome | 502 | |
| chr17:44,374,688–44,375,216 | 182.6 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 172.0 kb | Distal (>10kb) Multiome | 553 | |
| chr17:44,502,912–44,504,091 | 54.0 kb | Distal (>10kb) Multiome | 999 | |
| chr17:44,539,724–44,540,529 | 17.4 kb | Distal (>10kb) Multiome | 135 | |
| chr17:44,543,007–44,544,301 | 14.2 kb | Distal (>10kb) Multiome | 384 | |
| chr17:44,556,129–44,558,277 | 181 bp | At TSS Multiome | 696 | |
| chr17:44,608,340–44,608,975 | 51.1 kb | Distal (>10kb) Multiome | 208 | |
| chr17:44,628,394–44,629,188 | 71.2 kb | Distal (>10kb) Multiome | 285 | |
| chr17:44,656,036–44,656,706 | 98.9 kb | Distal (>10kb) Multiome | 280 | |
| chr17:44,689,325–44,690,416 | 132.4 kb | Distal (>10kb) Multiome HiCAR | 916 | |
| chr17:44,758,700–44,759,204 | 201.4 kb | Distal (>10kb) Multiome | 167 | |
| chr17:44,774,509–44,776,365 | 217.3 kb | Distal (>10kb) Multiome | 794 | |
| chr17:44,778,982–44,779,764 | 221.9 kb | Distal (>10kb) Multiome | 595 | |
| chr17:44,829,525–44,830,482 | 272.6 kb | Distal (>10kb) Multiome | 503 |
Genomic view of the FZD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.