This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FYN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FYN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FYN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:111,605,423–111,606,562 | 267.6 kb | Distal (>10kb) Multiome | 672 | |
| chr6:111,661,571–111,662,099 | 211.6 kb | Distal (>10kb) Multiome | 114 | |
| chr6:111,663,255–111,663,981 | 209.7 kb | Distal (>10kb) Multiome | 220 | |
| chr6:111,870,136–111,870,931 | 2.3 kb | Proximal (<10kb) | 150 | |
| chr6:111,871,814–111,873,910 | 36 bp | At TSS Multiome | 860 | |
| chr6:111,888,886–111,889,845 | 16.0 kb | Distal (>10kb) Multiome | 252 | |
| chr6:111,898,210–111,898,825 | 25.1 kb | Distal (>10kb) Multiome | 147 | |
| chr6:112,043,090–112,044,140 | 170.3 kb | Distal (>10kb) Multiome | 680 | |
| chr6:112,086,700–112,088,059 | 214.0 kb | Distal (>10kb) Multiome | 829 |
Genomic view of the FYN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.