FUT11
protein O-fucosyltransferase 4 | MGC33202, FUT11

Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Implicated in stomach cancer. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Apr 2025]

Developmental clusters: GC6
Biological processes 19 terms
Golgi membrane (GO:0000139)N-glycan processing (GO:0006491)N-glycan processing (GO:0006491)alpha-(1->3)-fucosyltransferase activity (GO:0046920)alpha-(1->3)-fucosyltransferase activity (GO:0046920)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)fucosyltransferase activity (GO:0008417)fucosyltransferase activity (GO:0008417)fucosyltransferase activity (GO:0008417)glycoprotein biosynthetic process (GO:0009101)membrane (GO:0016020)peptide-O-fucosyltransferase activity (GO:0046922)peptide-O-fucosyltransferase activity (GO:0046922)positive regulation of protein secretion (GO:0050714)positive regulation of protein secretion (GO:0050714)protein O-linked glycosylation (GO:0006493)protein binding (GO:0005515)
Expression (TPM)
FUT11 — as a Regulated Gene

TFs regulating FUT11 0 TFs

Transcription factors with Perturb-seq knockdown data for FUT11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FUT11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FUT11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FUT11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr10:73,495,235–73,496,398 276.4 kb Distal (>10kb) Multiome 908
chr10:73,591,236–73,591,781 180.8 kb Distal (>10kb) Multiome 359
chr10:73,591,961–73,592,227 180.2 kb Distal (>10kb) Multiome 458
chr10:73,625,111–73,626,369 146.3 kb Distal (>10kb) Multiome 810
chr10:73,647,157–73,648,042 124.8 kb Distal (>10kb) Multiome 238
chr10:73,730,165–73,730,854 41.8 kb Distal (>10kb) Multiome 823
chr10:73,741,689–73,742,673 30.1 kb Distal (>10kb) Multiome 190
chr10:73,743,801–73,744,894 27.9 kb Distal (>10kb) Multiome 962
chr10:73,771,782–73,773,237 502 bp At TSS Multiome 918
chr10:73,781,688–73,782,352 9.8 kb Proximal (<10kb) Multiome 721
chr10:73,785,180–73,785,869 13.2 kb Distal (>10kb) Multiome 745
chr10:73,810,828–73,812,285 39.6 kb Distal (>10kb) Multiome 876
chr10:73,817,045–73,817,772 45.1 kb Distal (>10kb) Multiome 123
chr10:73,823,062–73,824,101 51.3 kb Distal (>10kb) Multiome 130
chr10:73,873,847–73,875,246 102.4 kb Distal (>10kb) Multiome 654
chr10:73,906,669–73,907,201 134.6 kb Distal (>10kb) Multiome 417
chr10:73,910,388–73,911,812 138.8 kb Distal (>10kb) Multiome 486
chr10:73,965,730–73,966,725 194.0 kb Distal (>10kb) Multiome 552
chr10:73,994,650–73,995,392 222.9 kb Distal (>10kb) Multiome 69
chr10:73,997,294–73,999,626 225.6 kb Distal (>10kb) Multiome 964

Genome Browser

Genomic view of the FUT11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr10:73,485,235 – 74,009,626
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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