Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FRYL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRYL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRYL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:48,483,006–48,484,450 | 296.9 kb | Distal (>10kb) Multiome | 378 | |
| chr4:48,489,884–48,491,646 | 289.9 kb | Distal (>10kb) Multiome | 244 | |
| chr4:48,672,488–48,674,017 | 107.1 kb | Distal (>10kb) Multiome | 47 | |
| chr4:48,776,082–48,776,314 | 4.0 kb | Proximal (<10kb) | 11 | |
| chr4:48,776,526–48,776,762 | 3.5 kb | Proximal (<10kb) | 30 | |
| chr4:48,779,153–48,781,129 | 126 bp | At TSS Multiome | 820 | |
| chr4:48,830,446–48,831,681 | 50.8 kb | Distal (>10kb) Multiome | 800 | |
| chr4:48,906,159–48,907,243 | 126.5 kb | Distal (>10kb) Multiome | 490 | |
| chr4:48,914,069–48,914,976 | 134.2 kb | Distal (>10kb) Multiome | 105 | |
| chr4:48,985,704–48,986,746 | 205.9 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the FRYL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.