This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for FRMD4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRMD4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRMD4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:69,288,126–69,288,883 | 254.1 kb | Distal (>10kb) Multiome | 254 | |
| chr3:69,290,108–69,290,999 | 251.9 kb | Distal (>10kb) Multiome | 171 | |
| chr3:69,505,143–69,506,413 | 36.7 kb | Distal (>10kb) Multiome | 176 | |
| chr3:69,541,195–69,541,563 | 1.0 kb | Proximal (<10kb) | 94 | |
| chr3:69,541,656–69,543,081 | 4 bp | At TSS Multiome | 397 | |
| chr3:69,651,396–69,652,499 | 109.5 kb | Distal (>10kb) Multiome | 88 | |
| chr3:69,659,258–69,659,932 | 116.9 kb | Distal (>10kb) Multiome | 65 | |
| chr3:69,738,944–69,740,856 | 196.8 kb | Distal (>10kb) Multiome | 657 |
Genomic view of the FRMD4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.