The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for FRMD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRMD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRMD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,218,993–83,220,331 | 319.2 kb | Distal (>10kb) Multiome HiCAR | 472 | |
| chr9:83,536,923–83,539,150 | 99 bp | At TSS Multiome | 773 | |
| chr9:83,544,237–83,544,696 | 5.7 kb | Proximal (<10kb) | 252 | |
| chr9:83,622,459–83,623,894 | 84.6 kb | Distal (>10kb) Multiome | 774 | |
| chr9:83,630,907–83,631,624 | 92.7 kb | Distal (>10kb) Multiome | 194 | |
| chr9:83,706,859–83,708,822 | 168.6 kb | Distal (>10kb) Multiome | 1068 | |
| chr9:83,817,135–83,818,401 | 279.3 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the FRMD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.