This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for FOXRED1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXRED1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXRED1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:126,061,736–126,063,712 | 206.1 kb | Distal (>10kb) Multiome | 802 | |
| chr11:126,082,403–126,083,132 | 186.5 kb | Distal (>10kb) Multiome | 134 | |
| chr11:126,104,267–126,104,892 | 164.6 kb | Distal (>10kb) Multiome | 192 | |
| chr11:126,159,698–126,160,582 | 109.1 kb | Distal (>10kb) Multiome | 281 | |
| chr11:126,210,869–126,212,282 | 57.5 kb | Distal (>10kb) Multiome | 846 | |
| chr11:126,268,478–126,269,613 | 152 bp | At TSS Multiome | 828 | |
| chr11:126,282,310–126,283,787 | 13.9 kb | Distal (>10kb) Multiome | 754 | |
| chr11:126,303,694–126,304,639 | 34.9 kb | Distal (>10kb) Multiome | 979 | |
| chr11:126,345,823–126,346,956 | 77.2 kb | Distal (>10kb) Multiome | 446 | |
| chr11:126,355,100–126,356,405 | 86.5 kb | Distal (>10kb) Multiome | 596 | |
| chr11:126,440,475–126,441,596 | 171.8 kb | Distal (>10kb) Multiome | 367 | |
| chr11:126,480,538–126,481,044 | 211.7 kb | Distal (>10kb) Multiome | 487 | |
| chr11:126,497,641–126,499,015 | 229.3 kb | Distal (>10kb) Multiome | 250 | |
| chr11:126,502,215–126,503,760 | 234.0 kb | Distal (>10kb) Multiome | 129 |
Genomic view of the FOXRED1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.