This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for FNIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:158,571,551–158,572,520 | 197.0 kb | Distal (>10kb) Multiome | 128 | |
| chr4:158,670,728–158,672,956 | 98.1 kb | Distal (>10kb) Multiome | 1090 | |
| chr4:158,722,797–158,723,912 | 45.7 kb | Distal (>10kb) Multiome | 859 | |
| chr4:158,768,346–158,769,735 | 83 bp | At TSS Multiome | 747 | |
| chr4:158,782,620–158,783,783 | 14.0 kb | Distal (>10kb) Multiome | 413 | |
| chr4:158,902,258–158,903,267 | 133.7 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the FNIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.