This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for FMN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FMN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FMN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:239,809,722–239,811,934 | 281.8 kb | Distal (>10kb) Multiome | 344 | |
| chr1:239,997,239–239,998,357 | 94.1 kb | Distal (>10kb) Multiome | 321 | |
| chr1:240,032,004–240,034,115 | 58.3 kb | Distal (>10kb) Multiome HiCAR | 79 | |
| chr1:240,084,016–240,085,157 | 7.0 kb | Proximal (<10kb) Multiome | 198 | |
| chr1:240,091,321–240,094,015 | 16 bp | At TSS Multiome | 543 | |
| chr1:240,199,801–240,200,810 | 108.4 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the FMN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.