This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for FMN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FMN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FMN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:32,899,161–32,899,761 | 295.3 kb | Distal (>10kb) Multiome | 221 | |
| chr15:33,194,270–33,195,527 | 126 bp | At TSS Multiome | 320 | |
| chr15:33,196,181–33,196,408 | 1.5 kb | Proximal (<10kb) | 6 | |
| chr15:33,198,649–33,198,849 | 3.9 kb | Proximal (<10kb) | 12 | |
| chr15:33,201,905–33,202,212 | 7.2 kb | Proximal (<10kb) | 338 | |
| chr15:33,202,419–33,202,694 | 7.7 kb | Proximal (<10kb) | 25 | |
| chr15:33,310,489–33,311,874 | 116.2 kb | Distal (>10kb) Multiome | 240 |
Genomic view of the FMN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.