Transcription factors with Perturb-seq knockdown data for FLJ40194. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLJ40194 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLJ40194, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,944,483–48,945,203 | 286.0 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 233.5 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:49,013,253–49,014,714 | 216.8 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 208.3 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,031,811–49,032,444 | 198.5 kb | Distal (>10kb) Multiome | 423 | |
| chr17:49,035,641–49,036,299 | 194.8 kb | Distal (>10kb) Multiome | 338 | |
| chr17:49,191,794–49,193,465 | 38.1 kb | Distal (>10kb) Multiome | 1177 | |
| chr17:49,223,535–49,224,633 | 7.1 kb | Proximal (<10kb) Multiome | 281 | |
| chr17:49,227,458–49,227,721 | 3.1 kb | Proximal (<10kb) | 262 | |
| chr17:49,230,380–49,231,209 | 15 bp | At TSS Multiome | 496 | |
| chr17:49,260,115–49,260,840 | 29.6 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,361,317–49,363,214 | 131.5 kb | Distal (>10kb) Multiome | 873 | |
| chr17:49,371,314–49,372,084 | 140.9 kb | Distal (>10kb) Multiome | 235 | |
| chr17:49,414,619–49,415,442 | 184.2 kb | Distal (>10kb) Multiome | 829 | |
| chr17:49,486,189–49,486,812 | 255.6 kb | Distal (>10kb) Multiome | 147 | |
| chr17:49,494,780–49,495,773 | 264.4 kb | Distal (>10kb) Multiome | 386 | |
| chr17:49,496,269–49,496,902 | 265.7 kb | Distal (>10kb) Multiome | 440 | |
| chr17:49,497,462–49,497,966 | 267.1 kb | Distal (>10kb) Multiome | 280 | |
| chr17:49,508,179–49,508,962 | 277.7 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the FLJ40194 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.