Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FIBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FIBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FIBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,591,808–65,592,698 | 296.3 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 281.3 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 274.3 kb | Distal (>10kb) Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 272.9 kb | Distal (>10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 250.4 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 246.3 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 241.2 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 235.7 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 225.4 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 176.2 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 167.8 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 108.4 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 100.0 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 70.2 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 54.7 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 31.4 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 27.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 14.8 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,884,699–65,884,925 | 3.5 kb | Proximal (<10kb) | 422 | |
| chr11:65,887,987–65,889,162 | 99 bp | At TSS Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 2.2 kb | Proximal (<10kb) Multiome | 895 | |
| chr11:65,891,795–65,892,027 | 3.3 kb | Proximal (<10kb) | 526 | |
| chr11:65,899,867–65,900,779 | 12.1 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 30.8 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 73.2 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 113.9 kb | Distal (>10kb) Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 119.0 kb | Distal (>10kb) Multiome | 100 | |
| chr11:66,022,341–66,022,903 | 134.1 kb | Distal (>10kb) Multiome | 466 | |
| chr11:66,045,170–66,045,637 | 156.9 kb | Distal (>10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 160.7 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 163.7 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,069,690–66,071,102 | 181.7 kb | Distal (>10kb) Multiome | 622 |
Genomic view of the FIBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.