This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for FGFR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGFR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGFR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:1,512,763–1,513,500 | 280.0 kb | Distal (>10kb) Multiome | 317 | |
| chr4:1,578,390–1,579,916 | 214.1 kb | Distal (>10kb) Multiome | 472 | |
| chr4:1,580,022–1,580,836 | 212.6 kb | Distal (>10kb) Multiome | 412 | |
| chr4:1,683,721–1,685,162 | 108.8 kb | Distal (>10kb) Multiome | 624 | |
| chr4:1,711,443–1,713,255 | 80.7 kb | Distal (>10kb) Multiome | 1043 | |
| chr4:1,720,066–1,721,937 | 72.0 kb | Distal (>10kb) Multiome | 817 | |
| chr4:1,746,068–1,746,713 | 46.9 kb | Distal (>10kb) Multiome | 499 | |
| chr4:1,792,302–1,795,939 | 145 bp | At TSS Multiome | 784 | |
| chr4:1,809,836–1,810,515 | 16.9 kb | Distal (>10kb) Multiome | 554 | |
| chr4:1,855,368–1,857,225 | 63.0 kb | Distal (>10kb) Multiome | 849 | |
| chr4:1,870,118–1,872,300 | 77.8 kb | Distal (>10kb) Multiome | 962 | |
| chr4:2,008,507–2,010,125 | 215.9 kb | Distal (>10kb) Multiome | 1040 | |
| chr4:2,041,030–2,042,663 | 248.7 kb | Distal (>10kb) Multiome | 554 | |
| chr4:2,058,181–2,059,492 | 265.9 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the FGFR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.