Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FEM1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FEM1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FEM1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,262,382–115,263,400 | 281.9 kb | Distal (>10kb) Multiome | 905 | |
| chr5:115,295,823–115,297,287 | 248.2 kb | Distal (>10kb) Multiome | 763 | |
| chr5:115,384,667–115,385,510 | 159.6 kb | Distal (>10kb) Multiome | 108 | |
| chr5:115,543,835–115,545,478 | 43 bp | At TSS Multiome | 943 | |
| chr5:115,549,210–115,549,595 | 4.4 kb | Proximal (<10kb) | 207 | |
| chr5:115,550,756–115,551,144 | 6.0 kb | Proximal (<10kb) | 13 | |
| chr5:115,551,252–115,551,375 | 6.5 kb | Proximal (<10kb) | 33 | |
| chr5:115,601,724–115,602,813 | 57.4 kb | Distal (>10kb) Multiome | 542 | |
| chr5:115,625,502–115,626,687 | 81.4 kb | Distal (>10kb) Multiome | 976 | |
| chr5:115,785,567–115,786,155 | 241.0 kb | Distal (>10kb) Multiome | 90 | |
| chr5:115,815,539–115,817,207 | 271.9 kb | Distal (>10kb) Multiome | 490 | |
| chr5:115,840,887–115,842,729 | 297.1 kb | Distal (>10kb) Multiome | 1077 |
Genomic view of the FEM1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.