Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in clathrin-coated pit and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FCHSD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCHSD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCHSD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:72,722,329–72,722,710 | 419.7 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr11:72,813,727–72,815,115 | 327.9 kb | Distal (>10kb) Multiome HiCAR | 870 | |
| chr11:72,821,008–72,822,837 | 320.0 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr11:73,141,056–73,143,237 | 203 bp | At TSS Multiome | 1038 | |
| chr11:73,217,837–73,218,810 | 76.0 kb | Distal (>10kb) Multiome | 603 | |
| chr11:73,242,414–73,243,061 | 100.4 kb | Distal (>10kb) Multiome | 448 | |
| chr11:73,307,026–73,309,843 | 165.3 kb | Distal (>10kb) Multiome | 963 | |
| chr11:73,342,698–73,343,488 | 200.7 kb | Distal (>10kb) Multiome | 124 | |
| chr11:73,361,895–73,362,672 | 219.9 kb | Distal (>10kb) Multiome | 245 | |
| chr11:73,375,760–73,377,389 | 234.0 kb | Distal (>10kb) Multiome | 817 |
Genomic view of the FCHSD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.