FBXW9

F-box and WD repeat domain containing 9 | Fbw9, MEC-15, MGC10870

Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Developmental clusters: GC6

Biological processes 3 terms

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)cytosol (GO:0005829)protein binding (GO:0005515)

Expression (TPM)

TFs regulating FBXW9 0 TFs

Transcription factors with Perturb-seq knockdown data for FBXW9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXW9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FBXW9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXW9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:11,535,847–11,536,353	1160.5 kb	Distal (>10kb) Multiome HiCAR	694
chr19:11,539,738–11,540,434	1156.6 kb	Distal (>10kb) Multiome HiCAR	176
chr19:12,400,090–12,401,657	295.4 kb	Distal (>10kb) Multiome	671
chr19:12,440,217–12,441,483	255.6 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	211.8 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	201.2 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	145.1 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	124.9 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	85.7 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	56.4 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	48.9 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	39.5 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	29.9 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	27.1 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	15.2 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	3 bp	At TSS Multiome	806
chr19:12,702,968–12,703,602	6.6 kb	Proximal (<10kb) Multiome	121
chr19:12,721,692–12,723,084	25.8 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	27.4 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	38.1 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	40.5 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	61.2 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	69.6 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	78.8 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	81.3 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	86.1 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	93.4 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	94.9 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	97.1 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	105.3 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	109.9 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	129.2 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	136.0 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	137.3 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	141.8 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	144.2 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	151.1 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	171.0 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	176.7 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	184.9 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	188.8 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	194.4 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	216.7 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	222.8 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	237.1 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	241.8 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	249.3 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	260.6 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	268.8 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	287.0 kb	Distal (>10kb) Multiome	688

Genome Browser

Genomic view of the FBXW9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.