This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXO9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:52,413,171–52,413,920 | 651.9 kb | Distal (>10kb) Multiome HiCAR | 46 | |
| chr6:52,419,778–52,421,057 | 645.2 kb | Distal (>10kb) Multiome HiCAR | 913 | |
| chr6:52,855,940–52,856,582 | 209.1 kb | Distal (>10kb) Multiome | 166 | |
| chr6:52,861,065–52,861,720 | 204.0 kb | Distal (>10kb) Multiome | 105 | |
| chr6:52,994,589–52,996,420 | 70.0 kb | Distal (>10kb) Multiome HiCAR | 1101 | |
| chr6:53,060,233–53,060,576 | 4.9 kb | Proximal (<10kb) | 31 | |
| chr6:53,061,219–53,062,138 | 3.6 kb | Proximal (<10kb) Multiome | 961 | |
| chr6:53,064,550–53,066,422 | 418 bp | At TSS Multiome | 934 | |
| chr6:53,347,548–53,349,468 | 282.7 kb | Distal (>10kb) Multiome | 976 | |
| chr6:53,358,501–53,360,085 | 294.0 kb | Distal (>10kb) Multiome | 1019 |
Genomic view of the FBXO9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.