This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for FBXO33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:39,169,826–39,170,847 | 262.1 kb | Distal (>10kb) Multiome | 1008 | |
| chr14:39,174,486–39,175,885 | 257.4 kb | Distal (>10kb) Multiome | 1141 | |
| chr14:39,203,536–39,204,758 | 228.3 kb | Distal (>10kb) Multiome | 293 | |
| chr14:39,266,213–39,267,903 | 165.3 kb | Distal (>10kb) Multiome | 1124 | |
| chr14:39,431,232–39,433,633 | 121 bp | At TSS Multiome | 1121 |
Genomic view of the FBXO33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.