Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXO27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,734,491–38,735,702 | 297.2 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 295.5 kb | Distal (>10kb) Multiome | 493 | |
| chr19:38,754,913–38,755,455 | 277.3 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 200.7 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 180.5 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 162.5 kb | Distal (>10kb) Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 132.7 kb | Distal (>10kb) Multiome | 886 | |
| chr19:38,930,044–38,931,363 | 101.8 kb | Distal (>10kb) Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 82.6 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 55.8 kb | Distal (>10kb) Multiome | 846 | |
| chr19:38,995,916–38,996,388 | 36.4 kb | Distal (>10kb) Multiome | 144 | |
| chr19:39,030,958–39,033,042 | 928 bp | At TSS Multiome | 763 | |
| chr19:39,038,309–39,038,486 | 6.9 kb | Proximal (<10kb) | 156 | |
| chr19:39,125,485–39,126,290 | 93.2 kb | Distal (>10kb) Multiome | 866 | |
| chr19:39,307,021–39,308,955 | 275.0 kb | Distal (>10kb) Multiome | 358 | |
| chr19:39,320,514–39,321,175 | 288.3 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the FBXO27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.