FBXL19

F-box and leucine rich repeat protein 19 | CXXC11, DKFZp434K0410, Fbl19, JHDM1C

This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Member of: DE-2

Biological processes 20 terms

DNA binding (GO:0003677)SCF ubiquitin ligase complex (GO:0019005)SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)histone demethylase activity (GO:0032452)nucleus (GO:0005634)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)transcription coregulator activity (GO:0003712)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)unmethylated CpG binding (GO:0045322)unmethylated CpG binding (GO:0045322)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating FBXL19 0 TFs

Transcription factors with Perturb-seq knockdown data for FBXL19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FBXL19

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:30,634,070–30,634,986	289.2 kb	Distal (>10kb) Multiome	907
chr16:30,650,029–30,651,831	272.9 kb	Distal (>10kb) Multiome	992
chr16:30,657,638–30,659,894	265.3 kb	Distal (>10kb) Multiome	1053
chr16:30,677,814–30,678,622	245.4 kb	Distal (>10kb) Multiome	177
chr16:30,697,755–30,699,614	224.5 kb	Distal (>10kb) Multiome	1153
chr16:30,747,864–30,748,943	175.2 kb	Distal (>10kb) Multiome	824
chr16:30,761,380–30,762,606	161.3 kb	Distal (>10kb) Multiome HiCAR	885
chr16:30,774,965–30,776,186	148.0 kb	Distal (>10kb) Multiome	1025
chr16:30,786,385–30,788,019	136.4 kb	Distal (>10kb) Multiome	885
chr16:30,805,468–30,806,187	117.9 kb	Distal (>10kb) Multiome	969
chr16:30,814,045–30,814,733	109.1 kb	Distal (>10kb) Multiome	995
chr16:30,841,062–30,841,882	82.0 kb	Distal (>10kb) Multiome	49
chr16:30,874,866–30,875,643	48.2 kb	Distal (>10kb) Multiome	1108
chr16:30,893,485–30,894,587	29.4 kb	Distal (>10kb) Multiome	950
chr16:30,895,854–30,897,426	26.5 kb	Distal (>10kb) Multiome	822
chr16:30,901,969–30,902,794	21.2 kb	Distal (>10kb) Multiome	579
chr16:30,921,611–30,925,097	167 bp	At TSS Multiome	1132
chr16:30,927,705–30,928,596	4.6 kb	Proximal (<10kb) Multiome	274
chr16:30,941,803–30,942,254	18.5 kb	Distal (>10kb) Multiome	507
chr16:30,947,471–30,950,635	26.7 kb	Distal (>10kb) Multiome	1066
chr16:30,953,370–30,954,135	30.3 kb	Distal (>10kb) Multiome	499
chr16:30,956,960–30,958,498	34.1 kb	Distal (>10kb) Multiome	1022
chr16:30,984,837–30,985,709	61.6 kb	Distal (>10kb) Multiome	787
chr16:30,996,877–30,998,001	73.8 kb	Distal (>10kb) Multiome	759
chr16:31,010,379–31,011,032	87.1 kb	Distal (>10kb) Multiome	117
chr16:31,032,789–31,034,448	109.9 kb	Distal (>10kb) Multiome	1047
chr16:31,041,996–31,042,665	118.8 kb	Distal (>10kb) Multiome	213
chr16:31,072,597–31,074,957	149.9 kb	Distal (>10kb) Multiome	1167
chr16:31,094,132–31,095,139	171.3 kb	Distal (>10kb) Multiome	933
chr16:31,108,209–31,108,826	184.8 kb	Distal (>10kb) Multiome	733
chr16:31,117,128–31,118,265	194.2 kb	Distal (>10kb) Multiome	929
chr16:31,134,682–31,136,040	212.1 kb	Distal (>10kb) Multiome	450
chr16:31,138,695–31,139,457	215.5 kb	Distal (>10kb) Multiome	413
chr16:31,141,455–31,143,270	218.8 kb	Distal (>10kb) Multiome	856
chr16:31,148,229–31,148,775	224.9 kb	Distal (>10kb) Multiome	209
chr16:31,179,340–31,181,495	256.5 kb	Distal (>10kb) Multiome	1179
chr16:31,201,568–31,203,049	278.6 kb	Distal (>10kb) Multiome	507
chr16:31,214,606–31,216,091	291.7 kb	Distal (>10kb) Multiome	469

Genome Browser

Genomic view of the FBXL19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.