The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for FBXL18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,240,214–5,240,895 | 273.3 kb | Distal (>10kb) Multiome | 613 | |
| chr7:5,296,049–5,297,455 | 217.0 kb | Distal (>10kb) Multiome | 191 | |
| chr7:5,401,296–5,401,948 | 112.2 kb | Distal (>10kb) Multiome | 104 | |
| chr7:5,406,932–5,408,289 | 106.1 kb | Distal (>10kb) Multiome | 281 | |
| chr7:5,412,740–5,413,653 | 100.4 kb | Distal (>10kb) Multiome | 341 | |
| chr7:5,417,700–5,419,525 | 94.8 kb | Distal (>10kb) Multiome | 714 | |
| chr7:5,423,102–5,425,439 | 89.7 kb | Distal (>10kb) Multiome | 834 | |
| chr7:5,426,416–5,429,142 | 86.8 kb | Distal (>10kb) Multiome | 1072 | |
| chr7:5,450,591–5,451,143 | 62.9 kb | Distal (>10kb) Multiome | 306 | |
| chr7:5,486,725–5,487,360 | 26.7 kb | Distal (>10kb) Multiome | 621 | |
| chr7:5,494,650–5,495,099 | 18.9 kb | Distal (>10kb) Multiome | 515 | |
| chr7:5,513,480–5,514,175 | 96 bp | At TSS Multiome | 815 | |
| chr7:5,521,099–5,521,586 | 7.3 kb | Proximal (<10kb) | 105 | |
| chr7:5,522,168–5,524,589 | 8.4 kb | Proximal (<10kb) | 322 | |
| chr7:5,524,684–5,527,073 | 12.9 kb | Distal (>10kb) Multiome HiCAR | 736 | |
| chr7:5,529,088–5,532,313 | 16.2 kb | Distal (>10kb) Multiome HiCAR | 1081 | |
| chr7:5,554,765–5,555,676 | 41.5 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr7:5,555,801–5,557,053 | 42.9 kb | Distal (>10kb) Multiome HiCAR | 807 | |
| chr7:5,558,744–5,559,347 | 45.3 kb | Distal (>10kb) Multiome HiCAR | 525 | |
| chr7:5,562,000–5,564,024 | 48.3 kb | Distal (>10kb) Multiome | 859 | |
| chr7:5,569,367–5,570,943 | 56.5 kb | Distal (>10kb) Multiome | 694 | |
| chr7:5,574,238–5,575,433 | 61.2 kb | Distal (>10kb) Multiome | 447 | |
| chr7:5,591,580–5,596,769 | 79.0 kb | Distal (>10kb) Multiome | 1056 | |
| chr7:5,606,973–5,608,439 | 93.9 kb | Distal (>10kb) Multiome | 322 | |
| chr7:5,781,073–5,781,919 | 267.9 kb | Distal (>10kb) Multiome | 696 |
Genomic view of the FBXL18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.