Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXL13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:102,748,441–102,749,501 | 325.9 kb | Distal (>10kb) Multiome HiCAR | 433 | |
| chr7:102,933,530–102,934,088 | at TSS | At TSS | 162 | |
| chr7:102,934,772–102,934,981 | 1.0 kb | Proximal (<10kb) | 117 | |
| chr7:103,074,047–103,075,916 | 205 bp | At TSS Multiome | 860 | |
| chr7:103,078,197–103,078,458 | 3.6 kb | Proximal (<10kb) | 13 | |
| chr7:103,148,730–103,149,910 | 74.5 kb | Distal (>10kb) Multiome | 1002 | |
| chr7:103,279,769–103,280,793 | 205.6 kb | Distal (>10kb) Multiome | 291 | |
| chr7:103,297,040–103,297,853 | 222.7 kb | Distal (>10kb) Multiome | 880 | |
| chr7:103,344,148–103,345,138 | 270.0 kb | Distal (>10kb) Multiome | 994 | |
| chr7:103,347,517–103,348,162 | 272.9 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the FBXL13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.