Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FBRSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBRSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBRSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:132,189,320–132,190,290 | 300.4 kb | Distal (>10kb) Multiome | 452 | |
| chr12:132,437,261–132,437,736 | 52.7 kb | Distal (>10kb) Multiome | 153 | |
| chr12:132,488,556–132,491,043 | 170 bp | At TSS Multiome | 563 | |
| chr12:132,559,692–132,561,628 | 69.9 kb | Distal (>10kb) Multiome | 607 | |
| chr12:132,598,373–132,599,027 | 108.4 kb | Distal (>10kb) Multiome | 242 | |
| chr12:132,618,319–132,618,996 | 128.5 kb | Distal (>10kb) Multiome | 202 | |
| chr12:132,686,665–132,688,078 | 197.3 kb | Distal (>10kb) Multiome | 824 | |
| chr12:132,710,174–132,711,444 | 220.6 kb | Distal (>10kb) Multiome | 940 | |
| chr12:132,761,549–132,762,490 | 271.9 kb | Distal (>10kb) Multiome | 760 | |
| chr12:132,828,453–132,829,499 | 339.0 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the FBRSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.