Predicted to enable C-4 methylsterol oxidase activity. Involved in positive regulation of megakaryocyte differentiation and positive regulation of protein phosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAXDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAXDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAXDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:154,610,368–154,611,194 | 240.1 kb | Distal (>10kb) Multiome | 443 | |
| chr5:154,643,128–154,643,829 | 207.0 kb | Distal (>10kb) Multiome HiCAR | 15 | |
| chr5:154,646,817–154,647,698 | 203.2 kb | Distal (>10kb) Multiome HiCAR | 614 | |
| chr5:154,682,263–154,683,578 | 167.8 kb | Distal (>10kb) Multiome | 1040 | |
| chr5:154,691,307–154,691,923 | 159.0 kb | Distal (>10kb) Multiome | 229 | |
| chr5:154,712,302–154,714,063 | 137.9 kb | Distal (>10kb) Multiome | 426 | |
| chr5:154,754,315–154,757,528 | 95.5 kb | Distal (>10kb) Multiome | 1020 | |
| chr5:154,840,791–154,841,246 | 9.4 kb | Proximal (<10kb) | 217 | |
| chr5:154,842,756–154,843,602 | 7.5 kb | Proximal (<10kb) Multiome | 390 | |
| chr5:154,850,234–154,850,864 | 29 bp | At TSS Multiome | 450 | |
| chr5:154,857,098–154,858,937 | 7.8 kb | Proximal (<10kb) Multiome | 1044 | |
| chr5:154,937,538–154,938,682 | 87.6 kb | Distal (>10kb) Multiome | 907 | |
| chr5:154,940,587–154,941,516 | 90.4 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the FAXDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.