FARSA
phenylalanyl-tRNA synthetase subunit alpha | CML33, FARSL, FARSLA

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.44 Developmental clusters: GC1
Biological processes 24 terms
ATP binding (GO:0005524)RNA binding (GO:0003723)aminoacyl-tRNA ligase activity (GO:0004812)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)magnesium ion binding (GO:0000287)membrane (GO:0016020)nucleotide binding (GO:0000166)phenylalanine-tRNA ligase activity (GO:0004826)phenylalanine-tRNA ligase activity (GO:0004826)phenylalanine-tRNA ligase activity (GO:0004826)phenylalanine-tRNA ligase activity (GO:0004826)phenylalanine-tRNA ligase complex (GO:0009328)phenylalanine-tRNA ligase complex (GO:0009328)phenylalanyl-tRNA aminoacylation (GO:0006432)phenylalanyl-tRNA aminoacylation (GO:0006432)phenylalanyl-tRNA aminoacylation (GO:0006432)protein binding (GO:0005515)protein heterotetramerization (GO:0051290)tRNA aminoacylation (GO:0043039)tRNA binding (GO:0000049)
Expression (TPM)
FARSA — as a Regulated Gene

TFs regulating FARSA 0 TFs

Transcription factors with Perturb-seq knockdown data for FARSA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FARSA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FARSA

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FARSA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:12,639,899–12,640,614 293.5 kb Distal (>10kb) Multiome 454
chr19:12,647,538–12,648,022 286.0 kb Distal (>10kb) Multiome 126
chr19:12,656,871–12,657,566 276.5 kb Distal (>10kb) Multiome 254
chr19:12,666,317–12,667,225 266.9 kb Distal (>10kb) Multiome 495
chr19:12,669,351–12,669,939 264.2 kb Distal (>10kb) Multiome 777
chr19:12,681,003–12,682,117 252.3 kb Distal (>10kb) Multiome 994
chr19:12,696,035–12,696,970 237.1 kb Distal (>10kb) Multiome 806
chr19:12,702,968–12,703,602 230.5 kb Distal (>10kb) Multiome 121
chr19:12,721,692–12,723,084 211.3 kb Distal (>10kb) Multiome 807
chr19:12,723,726–12,724,142 209.6 kb Distal (>10kb) Multiome 539
chr19:12,734,221–12,735,284 199.0 kb Distal (>10kb) Multiome 882
chr19:12,736,470–12,737,780 196.6 kb Distal (>10kb) Multiome 742
chr19:12,757,454–12,758,297 175.9 kb Distal (>10kb) Multiome 588
chr19:12,765,876–12,766,545 167.4 kb Distal (>10kb) Multiome 557
chr19:12,774,659–12,776,025 158.3 kb Distal (>10kb) Multiome 803
chr19:12,777,481–12,778,589 155.8 kb Distal (>10kb) Multiome 661
chr19:12,782,418–12,783,038 151.0 kb Distal (>10kb) Multiome 699
chr19:12,789,543–12,790,654 143.7 kb Distal (>10kb) Multiome 717
chr19:12,790,960–12,793,231 142.2 kb Distal (>10kb) Multiome 1015
chr19:12,793,340–12,794,240 140.0 kb Distal (>10kb) Multiome 808
chr19:12,801,120–12,802,290 131.8 kb Distal (>10kb) Multiome 901
chr19:12,806,212–12,806,984 127.2 kb Distal (>10kb) Multiome 827
chr19:12,825,565–12,826,186 107.9 kb Distal (>10kb) Multiome 436
chr19:12,832,484–12,833,101 101.1 kb Distal (>10kb) Multiome 970
chr19:12,833,638–12,834,477 99.8 kb Distal (>10kb) Multiome 310
chr19:12,838,114–12,838,869 95.3 kb Distal (>10kb) Multiome 377
chr19:12,840,071–12,841,485 92.9 kb Distal (>10kb) Multiome 391
chr19:12,847,633–12,848,090 86.0 kb Distal (>10kb) Multiome 535
chr19:12,867,327–12,868,022 66.1 kb Distal (>10kb) Multiome 315
chr19:12,872,968–12,873,990 60.4 kb Distal (>10kb) Multiome 263
chr19:12,880,834–12,881,875 52.2 kb Distal (>10kb) Multiome 656
chr19:12,884,836–12,886,381 48.3 kb Distal (>10kb) Multiome 717
chr19:12,890,614–12,891,603 42.7 kb Distal (>10kb) Multiome 841
chr19:12,913,054–12,913,584 20.4 kb Distal (>10kb) Multiome 373
chr19:12,919,018–12,919,719 14.3 kb Distal (>10kb) Multiome 732
chr19:12,933,441–12,934,086 57 bp At TSS Multiome 789
chr19:12,937,426–12,939,166 4.7 kb Proximal (<10kb) Multiome 943
chr19:12,945,275–12,946,647 12.2 kb Distal (>10kb) Multiome 1015
chr19:12,956,801–12,957,360 23.5 kb Distal (>10kb) Multiome 747
chr19:12,964,998–12,965,862 31.7 kb Distal (>10kb) Multiome 733
chr19:12,983,506–12,983,997 50.0 kb Distal (>10kb) Multiome 688
chr19:13,051,485–13,052,169 118.1 kb Distal (>10kb) Multiome 649
chr19:13,061,195–13,061,672 127.8 kb Distal (>10kb) Multiome 544
chr19:13,069,469–13,070,306 136.1 kb Distal (>10kb) Multiome 334
chr19:13,093,620–13,094,260 160.2 kb Distal (>10kb) Multiome 411
chr19:13,095,079–13,096,870 161.8 kb Distal (>10kb) Multiome 501
chr19:13,102,495–13,103,074 169.1 kb Distal (>10kb) Multiome 606
chr19:13,116,411–13,117,080 183.0 kb Distal (>10kb) Multiome 812
chr19:13,117,979–13,119,416 184.5 kb Distal (>10kb) Multiome 699
chr19:13,149,468–13,156,577 216.6 kb Distal (>10kb) Multiome 1333
chr19:13,162,579–13,165,523 231.0 kb Distal (>10kb) Multiome 1112
chr19:13,167,359–13,168,023 234.0 kb Distal (>10kb) Multiome 764

Genome Browser

Genomic view of the FARSA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:12,629,899 – 13,178,023
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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