Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within Rac protein signal transduction and neuron remodeling. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FARP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FARP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FARP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:241,102,057–241,102,727 | 253.9 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:241,148,805–241,150,972 | 206.9 kb | Distal (>10kb) Multiome | 897 | |
| chr2:241,217,134–241,217,954 | 138.5 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 83.5 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 40.8 kb | Distal (>10kb) Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 1.2 kb | Proximal (<10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 104 bp | At TSS Multiome | 680 | |
| chr2:241,507,257–241,509,444 | 152.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:241,540,846–241,542,485 | 185.0 kb | Distal (>10kb) Multiome | 394 | |
| chr2:241,558,542–241,559,899 | 202.5 kb | Distal (>10kb) Multiome | 638 | |
| chr2:241,609,833–241,610,860 | 254.1 kb | Distal (>10kb) Multiome | 755 | |
| chr2:241,636,378–241,638,145 | 281.1 kb | Distal (>10kb) Multiome | 934 |
Genomic view of the FARP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.