This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for FAR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:29,148,402–29,150,308 | 227 bp | At TSS Multiome | 532 | |
| chr12:29,153,389–29,153,753 | 4.0 kb | Proximal (<10kb) | 62 | |
| chr12:29,154,946–29,155,544 | 5.6 kb | Proximal (<10kb) | 196 | |
| chr12:29,169,804–29,170,896 | 21.0 kb | Distal (>10kb) Multiome | 173 | |
| chr12:29,228,588–29,229,353 | 79.7 kb | Distal (>10kb) Multiome | 42 | |
| chr12:29,316,453–29,317,293 | 167.7 kb | Distal (>10kb) Multiome | 132 | |
| chr12:29,317,820–29,318,229 | 1.1 kb | Proximal (<10kb) | 226 | |
| chr12:29,380,457–29,381,649 | 231.9 kb | Distal (>10kb) Multiome | 752 |
Genomic view of the FAR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.