Involved in intracellular protein transport and vesicle tethering to Golgi. Located in cytoplasmic vesicle and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM91A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM91A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM91A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:123,235,684–123,236,295 | 532.5 kb | Distal (>10kb) Multiome HiCAR | 110 | |
| chr8:123,416,006–123,417,726 | 351.9 kb | Distal (>10kb) Multiome HiCAR | 823 | |
| chr8:123,479,357–123,480,359 | 288.7 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr8:123,539,997–123,542,004 | 227.0 kb | Distal (>10kb) Multiome HiCAR | 699 | |
| chr8:123,678,684–123,679,495 | 89.2 kb | Distal (>10kb) Multiome | 51 | |
| chr8:123,679,596–123,680,360 | 88.5 kb | Distal (>10kb) Multiome | 85 | |
| chr8:123,760,794–123,760,985 | 7.5 kb | Proximal (<10kb) | 142 | |
| chr8:123,766,285–123,766,500 | 2.0 kb | Proximal (<10kb) | 190 | |
| chr8:123,767,780–123,769,038 | 62 bp | At TSS Multiome | 744 | |
| chr8:123,922,126–123,922,699 | 154.0 kb | Distal (>10kb) Multiome | 615 | |
| chr8:124,473,813–124,475,636 | 706.3 kb | Distal (>10kb) Multiome HiCAR | 970 |
Genomic view of the FAM91A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.