Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM83F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM83F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM83F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:39,532,183–39,533,171 | 462.1 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr22:39,534,113–39,535,455 | 460.0 kb | Distal (>10kb) Multiome HiCAR | 621 | |
| chr22:39,968,248–39,969,062 | 26.3 kb | Distal (>10kb) Multiome | 99 | |
| chr22:39,990,819–39,991,036 | 3.9 kb | Proximal (<10kb) | 32 | |
| chr22:39,994,434–39,995,793 | 58 bp | At TSS Multiome | 287 | |
| chr22:39,998,047–39,998,299 | 3.1 kb | Proximal (<10kb) | 156 | |
| chr22:40,009,338–40,009,768 | at TSS | At TSS | 157 | |
| chr22:40,043,949–40,045,800 | 49.6 kb | Distal (>10kb) Multiome | 871 | |
| chr22:40,176,907–40,177,289 | 182.1 kb | Distal (>10kb) Multiome | 461 | |
| chr22:40,177,538–40,178,026 | 182.9 kb | Distal (>10kb) Multiome | 616 | |
| chr22:40,187,442–40,188,012 | 192.7 kb | Distal (>10kb) Multiome | 86 |
Genomic view of the FAM83F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.