Enables kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Located in cytosol; intercellular bridge; and mitotic spindle pole. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM83D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM83D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM83D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:38,646,005–38,646,460 | 280.1 kb | Distal (>10kb) Multiome | 567 | |
| chr20:38,673,746–38,675,067 | 251.9 kb | Distal (>10kb) Multiome | 446 | |
| chr20:38,725,938–38,726,412 | 200.4 kb | Distal (>10kb) Multiome | 218 | |
| chr20:38,727,220–38,727,813 | 199.0 kb | Distal (>10kb) Multiome | 231 | |
| chr20:38,730,955–38,731,938 | 195.1 kb | Distal (>10kb) Multiome | 646 | |
| chr20:38,747,701–38,748,998 | 178.2 kb | Distal (>10kb) Multiome | 909 | |
| chr20:38,804,662–38,806,744 | 121.6 kb | Distal (>10kb) Multiome | 532 | |
| chr20:38,825,817–38,826,402 | 100.3 kb | Distal (>10kb) Multiome | 502 | |
| chr20:38,893,515–38,894,286 | 32.5 kb | Distal (>10kb) Multiome | 473 | |
| chr20:38,925,940–38,927,103 | 134 bp | At TSS Multiome | 989 | |
| chr20:38,961,917–38,962,858 | 35.9 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:39,049,709–39,050,723 | 123.8 kb | Distal (>10kb) Multiome HiCAR | 898 |
Genomic view of the FAM83D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.