Predicted to enable RNA binding activity. Involved in several processes, including mRNA stabilization; negative regulation of macrophage activation; and negative regulation of protein export from nucleus. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM76B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM76B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM76B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:95,089,389–95,090,696 | 700.0 kb | Distal (>10kb) Multiome HiCAR | 660 | |
| chr11:95,144,387–95,145,222 | 644.9 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr11:95,149,652–95,152,295 | 639.9 kb | Distal (>10kb) Multiome HiCAR | 685 | |
| chr11:95,788,868–95,791,310 | 6 bp | At TSS Multiome | 1058 | |
| chr11:95,903,947–95,905,232 | 114.7 kb | Distal (>10kb) Multiome | 145 | |
| chr11:95,923,511–95,924,679 | 134.3 kb | Distal (>10kb) Multiome | 950 | |
| chr11:96,389,261–96,390,676 | 600.1 kb | Distal (>10kb) Multiome HiCAR | 898 |
Genomic view of the FAM76B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.