This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for FAM3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:121,328,641–121,330,705 | 66.3 kb | Distal (>10kb) Multiome | 554 | |
| chr7:121,395,470–121,396,843 | 47 bp | At TSS Multiome | 989 | |
| chr7:121,398,458–121,398,604 | 2.1 kb | Proximal (<10kb) | 30 | |
| chr7:121,438,063–121,439,112 | 42.3 kb | Distal (>10kb) Multiome | 360 | |
| chr7:121,531,284–121,532,207 | 135.4 kb | Distal (>10kb) Multiome | 222 | |
| chr7:121,539,422–121,540,147 | 143.5 kb | Distal (>10kb) Multiome | 125 |
Genomic view of the FAM3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.