Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for FAM241B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM241B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM241B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:69,329,639–69,330,213 | 300.3 kb | Distal (>10kb) Multiome | 155 | |
| chr10:69,375,626–69,376,241 | 254.3 kb | Distal (>10kb) Multiome | 178 | |
| chr10:69,392,338–69,392,832 | 237.6 kb | Distal (>10kb) Multiome | 454 | |
| chr10:69,408,469–69,409,338 | 221.4 kb | Distal (>10kb) Multiome | 705 | |
| chr10:69,449,843–69,450,266 | 180.3 kb | Distal (>10kb) Multiome | 301 | |
| chr10:69,450,797–69,452,284 | 178.8 kb | Distal (>10kb) Multiome | 508 | |
| chr10:69,568,733–69,569,392 | 61.2 kb | Distal (>10kb) Multiome | 99 | |
| chr10:69,573,228–69,573,810 | 56.7 kb | Distal (>10kb) Multiome | 284 | |
| chr10:69,623,196–69,623,572 | 6.7 kb | Proximal (<10kb) | 9 | |
| chr10:69,629,756–69,630,921 | 1 bp | At TSS Multiome | 567 | |
| chr10:69,639,304–69,639,512 | 9.1 kb | Proximal (<10kb) | 131 | |
| chr10:69,801,126–69,803,261 | 172.7 kb | Distal (>10kb) Multiome | 527 | |
| chr10:69,876,839–69,877,624 | 247.0 kb | Distal (>10kb) Multiome | 45 |
Genomic view of the FAM241B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.