Involved in cellular response to estradiol stimulus and positive regulation of erythrocyte differentiation. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM210B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM210B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM210B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:54,385,104–54,385,871 | 1973.5 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr20:54,474,748–54,476,808 | 1883.4 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr20:54,849,030–54,850,253 | 1509.2 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr20:55,028,728–55,030,077 | 1329.5 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr20:56,348,867–56,349,029 | 9.9 kb | Proximal (<10kb) | 27 | |
| chr20:56,358,373–56,359,678 | 86 bp | At TSS Multiome | 612 | |
| chr20:56,359,800–56,360,113 | 827 bp | At TSS | 442 | |
| chr20:56,360,806–56,361,161 | 1.8 kb | Proximal (<10kb) | 96 | |
| chr20:56,362,865–56,363,077 | 3.9 kb | Proximal (<10kb) | 295 | |
| chr20:56,391,539–56,393,046 | 33.4 kb | Distal (>10kb) Multiome | 1080 | |
| chr20:56,468,222–56,468,931 | 109.6 kb | Distal (>10kb) Multiome | 887 | |
| chr20:56,624,898–56,625,604 | 266.1 kb | Distal (>10kb) Multiome | 210 | |
| chr20:56,628,380–56,631,136 | 271.4 kb | Distal (>10kb) Multiome | 551 |
Genomic view of the FAM210B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.