Transcription factors with Perturb-seq knockdown data for FAM193A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM193A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM193A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:2,241,509–2,242,666 | 294.4 kb | Distal (>10kb) Multiome | 783 | |
| chr4:2,261,141–2,263,069 | 274.3 kb | Distal (>10kb) Multiome | 806 | |
| chr4:2,401,939–2,402,479 | 134.4 kb | Distal (>10kb) Multiome | 317 | |
| chr4:2,413,008–2,413,630 | 123.2 kb | Distal (>10kb) Multiome | 564 | |
| chr4:2,417,912–2,419,213 | 117.8 kb | Distal (>10kb) Multiome | 628 | |
| chr4:2,462,245–2,463,183 | 73.9 kb | Distal (>10kb) Multiome | 643 | |
| chr4:2,468,399–2,469,652 | 67.6 kb | Distal (>10kb) Multiome | 858 | |
| chr4:2,535,307–2,537,785 | 216 bp | At TSS Multiome | 860 | |
| chr4:2,755,816–2,757,021 | 219.7 kb | Distal (>10kb) Multiome | 760 | |
| chr4:2,763,947–2,764,427 | 227.6 kb | Distal (>10kb) Multiome | 311 | |
| chr4:2,792,387–2,793,280 | 256.3 kb | Distal (>10kb) Multiome | 561 | |
| chr4:2,800,892–2,801,392 | 264.5 kb | Distal (>10kb) Multiome | 538 | |
| chr4:2,817,772–2,818,865 | 281.6 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the FAM193A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.